CXCL10
1 paper3 findings
- 1 lab in 1 country
- Funder: Academy of Scientific and Innovative Research
- Animals1
Outcomes
3Cellular senescence
upin mouse cells1
1 study
Cellular senescence
upin mouse cells1
CXCL10 increases cellular senescence in mouse cells.
“we treated the primary cortical neuron (Days in vitro : DIV 7-8) with CXCL10 and found increased senescence in CXCR3 dependent fashion.”
CellsDays in vitro 7–8; CXCR3-dependent effectprimary cortical neuron
CXCL10/CXCR3 Signaling Induces Neural Senescence and Cognitive Impairments
bioRxiv (Cold Spring Harbor Laboratory)18 Oct 2024Preprint
Learning and memory
downin mice1
1 study
Learning and memory
downin mice1
CXCL10 impairs learning and memory in mice.
“chronic infusion of CXCL10 induced learning and memory deficits in Y-maze, social recognition, contextual freeze tests”
AnimalsC57BL/6J mice; intracerebroventricular infusion0.5 pg/ hrs28 days
CXCL10/CXCR3 Signaling Induces Neural Senescence and Cognitive Impairments
bioRxiv (Cold Spring Harbor Laboratory)18 Oct 2024Preprint
P16 INK4a, P21 Cip1 and P53 expression
upin mice1
1 study
P16 INK4a, P21 Cip1 and P53 expression
upin mice1
CXCL10 increases P16 INK4a, P21 Cip1 and P53 expression in mice.
“We observed increased expression of senescent marker proteins p16 INK4a , p21 Cip1 , p53”
AnimalsC57BL/6J mice; intracerebroventricular infusionprefrontal cortex0.5 pg/ hrs28 days
CXCL10/CXCR3 Signaling Induces Neural Senescence and Cognitive Impairments
bioRxiv (Cold Spring Harbor Laboratory)18 Oct 2024Preprint