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Cu-nad@cm

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funders: National Key Research and Development Program of China and 1 more
  • Animals1

Outcomes

3

Cellular senescence

downin mice1

1 study

  1. Cu-nad@cm decreases cellular senescence in mice.

    “reveals the significant therapeutic potential of the Cu-NAD@CM system in managing atherosclerosis (a disease involving multiple senescent cell types) and in doxorubicin-induced and d-galactose-induced senescent mouse models.”

    Animalsin doxorubicin-induced and d-galactose-induced senescent mouse models

    A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senescence-Associated Phenotypes

    ACS nano5 Sep 2025

More on Cellular senescence

Atherosclerosis

downin mice1

1 study

  1. Cu-nad@cm protects against atherosclerosis in mice.

    “Our study reveals the significant therapeutic potential of the Cu-NAD@CM system in managing atherosclerosis (a disease involving multiple senescent cell types)”

    Animalsin managing atherosclerosis

    A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senescence-Associated Phenotypes

    ACS nano5 Sep 2025

More on Atherosclerosis

Senescence-associated secretory phenotype (SASP)

downin mice1

1 study

  1. Cu-nad@cm inhibits senescence-associated secretory phenotype (SASP) in mice.

    “Cu-NAD@CM system can target and recognize senescent cells while restoring the NADH to NAD+ cycle and inhibiting senescence-associated secretory phenotype (SASP) expression”

    Animalsproof of concept

    A Targeting Senescence and Recycling Intracellular Nicotinamide Adenine Dinucleotide Strategy for Attenuation of Senescence-Associated Phenotypes

    ACS nano5 Sep 2025

More on Senescence-associated secretory phenotype (SASP)

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