CT1812

Intervention1 paper4 findings

Animals1

Outcomes

4

NLRP3 inflammasome

downin mice1Very low certainty

1 study

CT1812 inhibits NLRP3 inflammasome in mice.
Animalsin microglia of aged surgical micehippocampus3 mg/kgdays 0-3males
CT1812 Attenuates Surgery-Induced Cognitive Impairment and Modulates TMEM97- and PGRMC1-Associated Hippocampal Stress Responses in Aged Mice · Neurochemical research · 21 Aug 2026

NLRP3 inflammasome →

ER unfolded protein response

downin mice1Very low certainty

1 study

CT1812 inhibits ER unfolded protein response in mice.
Animalsin hippocampal neurons of aged surgical micehippocampus3 mg/kgdays 0-3males
CT1812 Attenuates Surgery-Induced Cognitive Impairment and Modulates TMEM97- and PGRMC1-Associated Hippocampal Stress Responses in Aged Mice · Neurochemical research · 21 Aug 2026

ER unfolded protein response →

Anxiety

downin mice1Very low certainty

1 study

CT1812 decreases anxiety in mice.
Animalsin aged surgical mice3 mg/kgdays 0-3males
CT1812 Attenuates Surgery-Induced Cognitive Impairment and Modulates TMEM97- and PGRMC1-Associated Hippocampal Stress Responses in Aged Mice · Neurochemical research · 21 Aug 2026

Spatial memory

upin mice1Very low certainty

1 study

CT1812 improves spatial memory in mice.
Animalsin aged surgical mice3 mg/kgdays 0-3males
CT1812 Attenuates Surgery-Induced Cognitive Impairment and Modulates TMEM97- and PGRMC1-Associated Hippocampal Stress Responses in Aged Mice · Neurochemical research · 21 Aug 2026

Latest

1

Neurochemical ResearchAnimals21 Aug

CT1812 Attenuates Surgery-Induced Cognitive Impairment and Modulates TMEM97- and PGRMC1-Associated Hippocampal Stress Responses in Aged Mice