Coniferaldehyde

1. Coniferaldehyde has no effect on lifespan in worms.

   “CFA did not have any role in the lifespan extension of the several mutants linked to the AAK-2/AMPK pathway”

   Model organismsin mutants linked to the AAK-2/AMPK pathway

   Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway

   Biogerontology·14 Dec 2024

2. Coniferaldehyde extends lifespan in worms.

   “CFA could lower oxidative stress and enhance the lifespan of C. elegans by activating the PAR-4/LKB-1-AAK-2/AMPK-SKN-1/NRF-2 pathway”

   Model organisms

   Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway

   Biogerontology·14 Dec 2024

1. Coniferaldehyde decreases oxidative stress and ROS signalling in worms.

   “50 μM CFA could significantly activate autophagy and reduce oxidative stress”

   Model organisms50 μM

   Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway

   Biogerontology·14 Dec 2024

More on Oxidative stress and ROS signalling

1. Coniferaldehyde activates autophagy in worms.

   “50 μM CFA could significantly activate autophagy and reduce oxidative stress”

   Model organisms50 μM

   Coniferaldehyde activates autophagy and enhances oxidative stress resistance and lifespan of Caenorhabditis elegans via par-4/aak-2/skn-1 pathway

   Biogerontology·14 Dec 2024

More on Autophagy