Compound C7

1. Compound C7 inhibits cellular senescence in human cells.

   “suppression of NFκB and IL-10 inflammatory signaling and attenuation of stress/senescence‐associated markers”

   Cellsex vivo expansion

   Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells

   Stem cells translational medicine·Jun 27, 2026

More on Cellular senescence

1. Compound C7 improves multilineage reconstitution in humans.

   “C7 treatment enhances hematopoietic stem cell self-renewal and in vivo multilineage reconstitution”

   Animalsex vivo expansion

   Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells

   Stem cells translational medicine·Jun 27, 2026

1. Compound C7 decreases oxidative stress and ROS signalling in human cells.

   “limiting mitochondrially-derived reactive oxygen species production linked to oxidative stress”

   Cellsdirect culture with pre-isolated HSPCsumbilical cord blood

   Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells

   Stem cells translational medicine·Jun 27, 2026

More on Oxidative stress and ROS signalling

1. Compound C7 increases HSPC proliferation in human cells.

   “C7 preferentially enhances the proliferation and viability of early HSPC subsets”

   Cellsdirect culture with pre-isolated HSPCsumbilical cord blood

   Inhibition of inflammation and senescence with azole compound C7 enables expansion of hematopoietic stem and progenitor cells

   Stem cells translational medicine·Jun 27, 2026