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Compound 21

Intervention

2 papers study it1 more mentions it4 findings

PubChemMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Augusta University and 6 more
  • Animals1
  • Cells1

Outcomes

4

Ischemic lesion resolution

upin rats1

1 study

  1. Compound 21 improves ischemic lesion resolution in rats.

    “C21 enhanced sensorimotor recovery and ischemic lesion resolution at week 8.”

    Animalspost-stroke8 weeks

    Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats

    Translational stroke research

Sensorimotor recovery

upin rats1

1 study

  1. Compound 21 improves sensorimotor recovery in rats.

    “C21 enhanced sensorimotor recovery and ischemic lesion resolution at week 8.”

    Animalspost-stroke8 weeks

    Angiotensin II Type 2 Receptor Agonism Alleviates Progressive Post-stroke Cognitive Impairment in Aged Spontaneously Hypertensive Rats

    Translational stroke research

Oxidative stress and ROS signaling

downin mouse cells1

1 study

  1. Compound 21 decreases oxidative stress and ROS signaling in mouse cells.

    “Combination treatment induced significant changes in the levels of superoxide anion, the expressions of p21 and pRb, and the ratio of LC3B II/I expression, which were also significantly attenuated by C21 treatment.”

    Cellsin Ang II- and high glucose-treated VSMCsaorta

    AT2 Receptor Stimulation Inhibits Vascular Smooth Muscle Cell Senescence Induced by Angiotensin II and Hyperglycemia

    American journal of hypertension

More on Oxidative stress and ROS signaling

Cellular senescence

downin mouse cells1

1 study

  1. Compound 21 decreases cellular senescence in mouse cells.

    “which was almost completely attenuated by C21 treatment”

    Cellsin Ang II- and high glucose-treated VSMCsaorta

    AT2 Receptor Stimulation Inhibits Vascular Smooth Muscle Cell Senescence Induced by Angiotensin II and Hyperglycemia

    American journal of hypertension

More on Cellular senescence

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