Compound 1

4 papers2 findings

2 independent labs in 2 countries

Funder: University of Nottingham

Animals1
Model organisms3

Outcomes

1

Lifespan

upin worms2+12%

2 studies

Compound 1 extends lifespan in worms (up to 12%).
“alkaloids 1, 7-9, 14, and 17 significantly extended the lifespan of Caenorhabditis elegans by up to 12 % compared to the control group.”
Model organisms
Promorphinan and bisaporphine alkaloids from Alseodaphne peduncularis
Fitoterapia23 Jul 2025
Compound 1 extends lifespan in worms.
“compounds 1, 2, 5, 6, 8, and 9 (50 μM) significantly extended the mean survival time of C. elegans”
Model organismscompared with the blank control group50 μM
Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Celastrus virens with lifespan-extending effect on the nematode Caenorhabditis elegans
Fitoterapia23 Feb 2022

Latest

2 in 12 months

Cancer Cell International7 May

In silico screening, synthesis, and biological evaluation of pyrazolopyrimidine-derived mTOR inhibitors for anticancer and senomorphic effects

Experiments in animalsmTOR inhibitors

Phytochemistry2 Apr

Benstolizidines A-E: Indolizidine- and piperidine-type alkaloids from Benstonea parva

Experiments in wormsInterventions

Fitoterapia28 Jul

Promorphinan and bisaporphine alkaloids from Alseodaphne peduncularis

Experiments in wormsInterventions

Fitoterapia27 Feb

Dihydro-β-agarofuran-type sesquiterpenoids from the seeds of Celastrus virens with lifespan-extending effect on the nematode Caenorhabditis elegans

Experiments in wormsInterventions