Compound 8

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Natural Science Foundation of China

Model organisms1

Outcomes

Locomotion

upin worms1

1 study

Compound 8 improves locomotion in worms.
“They also improved pharyngeal pumping and locomotion”
Model organisms
Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans
Phytochemistry2 Mar 2026

Lifespan

upin worms1+31%

1 study

Compound 8 extends lifespan in worms (up to 30.8%).
“Both compounds significantly extended lifespan across multiple doses (up to 30.8% for compound 8 and 30.4% for compound 5)”
Model organismsacross multiple doses
Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans
Phytochemistry2 Mar 2026