Collagen iv + rgd

1. Collagen iv + rgd improves graft survival in mice (211 ± 24.1 days vs 125 ± 19.7 days).

   “Islets in microcapsules containing collagen IV and RGD survived 211 ± 24.1 days while controls survived 125 ± 19.7 days.”

   Animalsin immune-competent mice

   Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo

   Acta biomaterialia·Jan 5, 2023

1. Collagen iv + rgd decreases fibrosis in mice (5.8-fold fewer).

   “Also, 5.8-fold fewer capsules were affected by fibrosis.”

   Animalsin immune-incompetent mice

   Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo

   Acta biomaterialia·Jan 5, 2023

1. Collagen iv + rgd increases glucose-induced insulin release in mice (9.6-fold).

   “oxygen consumption rate by 14.3-fold and glucose-induced insulin release by 9.6-fold.”

   Animalsin immune-incompetent mice8-week

   Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo

   Acta biomaterialia·Jan 5, 2023

More on Glucose-induced insulin release

1. Collagen iv + rgd increases bioluminescence in mice (3.2-fold).

   “It enhanced after 8-week implantation in immune-incompetent mice the bioluminescence of allogeneic islets by 3.2-fold”

   Animalsin immune-incompetent mice8-week

   Extracellular matrix inclusion in immunoisolating alginate-based microcapsules promotes longevity, reduces fibrosis, and supports function of islet allografts in vivo

   Acta biomaterialia·Jan 5, 2023

More on Bioluminescence