Cognitive task

3 papers2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Région Occitanie Pyrénées-Méditerranée

Human trial1
Humans2

Outcomes

Pre-ejection period reactivity

downin humans1

1 study

Cognitive task decreases pre-ejection period reactivity in humans.
“PEP reactivity was shown to be a transient phenomenon, decreasing both over the course of each task (only significant during the first minute) and across repeated sessions.”
Human trial
Inhibition control and cardiac reactivity in young and middle-aged adults
Biological psychology16 Oct 2025