Cobalt oxide nanoparticles

1. Cobalt oxide nanoparticles induce inflammation in rats.

   “Exposure of aged rats to Co3O4-NPs resulted also in the overexpression of pro-inflammatory markers (TNF-α, IL-6, and.. NF-kB) in the cortex and striatum.”

   Animalssubacute exposure (1 and 4 mg/kg bw.S.C.28 days)cortex and striatummales

   Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence

   Biological trace element research·8 Mar 2025

More on Inflammation

1. Cobalt oxide nanoparticles induce oxidative stress and ROS signalling in rats.

   “Exposure of aged rats to Co3O4-NPs induced an elevation of indicators oxidative injury [protein oxidation (PCO), malondialdehyde (MDA), and advanced oxidation protein products (AOPP)]”

   Animalssubacute exposure (1 and 4 mg/kg bw.S.C.28 days)cortex and striatummales

   Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence

   Biological trace element research·8 Mar 2025

More on Oxidative stress and ROS signalling

1. Cobalt oxide nanoparticles increase depressive-like behavior in rats.

   “along with depressive-like behavior, as evidenced by prolonged immobility durations in the tail suspension test (TST) and Forced swimming test (FST).”

   Animalssubacute exposure (1 and 4 mg/kg bw.S.C.28 days)cortex and striatummales

   Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence

   Biological trace element research·8 Mar 2025

1. Cobalt oxide nanoparticles increase anxiety-like behavior in rats.

   “Heightened anxiety-like behavior was also observed in the Marble Burying test (MBT) and Open-field test (OFT)”

   Animalssubacute exposure (1 and 4 mg/kg bw.S.C.28 days)cortex and striatummales

   Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence

   Biological trace element research·8 Mar 2025

1. Cobalt oxide nanoparticles impair cognitive function in rats.

   “In addition, Co3O4-NPs exhibited cognitive deficits in the Novel Object Recognition Test (NORT), as demonstrated by a decrease in the discrimination index.”

   Animalssubacute exposure (1 and 4 mg/kg bw.S.C.28 days)cortex and striatummales

   Toxicological Alterations Induced by Subacute Exposure of Cobalt Oxide Nanoparticles in Aged Rats: Behavioral, Biochemical, Molecular, and Histopathological Evidence

   Biological trace element research·8 Mar 2025