Clopidogrel

1 paper6 findings

PubChem 60606 ChEBI 37941 MeSH D000077144

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funders: Hunter New England Local Health District and 2 more

Animals1

Outcomes

5

Amyloid-beta

upin mice1

1 study

Clopidogrel increases amyloid-beta in mice.
“altered microglia activity, and increased amyloid beta levels in the peri-infarct region.”
Animalsfollowing photothrombotic strokeperi-infarct brain region14 days; analyzed on day 15males
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke
International journal of molecular sciences10 Mar 2026

More on Amyloid-beta

Vascular permeability

upin mice1

1 study

Clopidogrel increases vascular permeability in mice.
“Clopidogrel treatment significantly reduced survival and body weight, decreased vessel density, increased vascular permeability”
Animalsfollowing photothrombotic strokebrain14 days; analyzed on day 15males
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke
International journal of molecular sciences10 Mar 2026

Vessel density

downin mice1

1 study

Clopidogrel decreases vessel density in mice.
“Clopidogrel treatment significantly reduced survival and body weight, decreased vessel density”
Animalsfollowing photothrombotic strokebrain14 days; analyzed on day 15males
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke
International journal of molecular sciences10 Mar 2026

Body weight

downin mice1

1 study

Clopidogrel decreases body weight in mice.
“Clopidogrel treatment significantly reduced survival and body weight”
Animalsfollowing photothrombotic stroke14 daysmales
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke
International journal of molecular sciences10 Mar 2026

Survival

downin mice1

1 study

Clopidogrel decreases survival in mice.
“Clopidogrel treatment significantly reduced survival and body weight”
Animalsfollowing photothrombotic stroke14 daysmales
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke
International journal of molecular sciences10 Mar 2026

Associations

1

Microglia activity

mixedin mice1

1 study

Clopidogrel is associated with microglia activity in mice.
“Clopidogrel treatment significantly reduced survival and body weight, decreased vessel density, increased vascular permeability, altered microglia activity”
Animalsfollowing photothrombotic strokebrain14 days; analyzed on day 15males
Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke
International journal of molecular sciences10 Mar 2026

Latest

2 in 12 months

International Journal of Molecular Sciences28 Mar

Clopidogrel Administration Impairs Neurovascular Unit Recovery and Exacerbates Amyloid Beta Accumulation in Aged Mice Post-Stroke

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