CLK-1 knockdown

1. CLK-1 knockdown improves oxygen consumption rate in worms.

   “co-knockdown of psd-1 along with the ETC component clk-1 rescued physiological defects such as restoring the lifespan of from 13.48 ± 0.51 days psd-1 RNAi worms to 17.36 ± 0.44 days in psd-1 ; clk-1 double-knockdown worms and normalizing oxygen consumption rate”

   Model organismsco-knockdown with psd-1RNAi

   Suppressing clk-1 restores lifespan and mitochondrial function in psd-1 deficient worms · Antioxidants (Basel, Switzerland) · 20 Sep 2026

Oxygen consumption rate →

1. CLK-1 knockdown extends lifespan in worms (from 13.48 ± 0.51 days to 17.36 ± 0.44 days).

   “restoring the lifespan of from 13.48 ± 0.51 days psd-1 RNAi worms to 17.36 ± 0.44 days in psd-1 ; clk-1 double-knockdown worms”

   Model organismsin psd-1 RNAi backgroundRNAi

   Suppressing clk-1 restores lifespan and mitochondrial function in psd-1 deficient worms · Antioxidants (Basel, Switzerland) · 20 Sep 2026