Circulating extracellular vesicles

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: National Science and Technology Council and 3 more

Humans1
Cells1

Outcomes

Cell viability

no changein mouse cells1

1 study

Circulating extracellular vesicles have no effect on cell viability in mouse cells.
“EVs exerted no direct protective effect on hypoxic TECs, and no significant differences were observed between Y_EVs and O_EVs in any condition.”
Cellsin hypoxic renal tubular epithelial cells
Investigating the roles of macrophage age and circulating extracellular vesicles in cytoprotection of hypoxic renal tubular cell stress
BMC molecular and cell biology25 Mar 2026

Senescence-associated secretory phenotype (SASP)

upin human cells1

1 study

Circulating extracellular vesicles induce senescence-associated secretory phenotype (SASP) in human cells.
“increased levels of TNF-α, IL-1β, IFN-γ, IL-8, and CCL11, accompanied by the expression of p16 INK4a in HMC3 cells, suggesting a proinflammatory, senescence-associated secretory phenotype (SASP).”
Cellsplasma-derived extracellular vesicles from Parkinson’s disease patientsHMC3 microglia
Circulating extracellular vesicles drive microglial senescence and neurodegeneration in Parkinson’s disease
bioRxiv (Cold Spring Harbor Laboratory)12 Mar 2026Preprint

More on Senescence-associated secretory phenotype (SASP)

Axonal degeneration and neuronal cell death

upin human cells1

1 study

Circulating extracellular vesicles induce axonal degeneration and neuronal cell death in human cells.
“PD-EV induced axonal degeneration and cell death in SH-SY5Y neurons”
Cellsplasma-derived extracellular vesicles from Parkinson’s disease patientsSH-SY5Y neurons
Circulating extracellular vesicles drive microglial senescence and neurodegeneration in Parkinson’s disease
bioRxiv (Cold Spring Harbor Laboratory)12 Mar 2026Preprint