Circadian rhythm disruption combined with a high-fat, high-sugar diet

1. Circadian rhythm disruption combined with a high-fat, high-sugar diet impairs cognitive and motor function in mice.

   “as well as obvious cognitive and motor impairments.”

   ReviewC57BL/6J composite model compared with single-factor controls

   A Combinatorial Mouse Model of Circadian Disruption and Dietary Stress for Investigating Lifestyle-Accelerated Aging Pathophysiology

   Journal of visualized experiments : JoVE·28 Apr 2026

1. Circadian rhythm disruption combined with a high-fat, high-sugar diet increases metabolic disorders in mice.

   “Compared with controls, the composite model showed more severe metabolic disorders, including increased body weight, elevated fasting glucose and lipid levels, and marked hepatic steatosis”

   ReviewC57BL/6J composite model compared with single-factor high-fat, high-sugar diet and circadian disruption controls

   A Combinatorial Mouse Model of Circadian Disruption and Dietary Stress for Investigating Lifestyle-Accelerated Aging Pathophysiology

   Journal of visualized experiments : JoVE·28 Apr 2026

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