Circadian rhythm

2 papers3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funders: FONDATION ALZHEIMER and 4 more

Humans2

Associations

CSF2RB

upin humans1

1 study

Circadian rhythm is associated with CSF2RB in humans.
“within‐day fragmentation (intradaily variability) was positively associated with colony stimulating factor 2 receptor beta.”
Humanscognitively normalplasma57% femalesn = 54
Sleep and 24‐hour rhythm associations with plasma markers of inflammation in aging
AAIC 2025 abstract10 Jan 2026