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Chondroitinase abc

Intervention

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

  • 2 independent labs in 2 countries
  • Funders: Department of Biotechnology, Ministry of Science and Technology, India and 1 more
  • Animals1

Outcomes

3

Plaque size and number

downin mice1

1 study

  1. Chondroitinase abc decreases plaque size and number in mice.

    “Intrahippocampal targeting of the ECM appears to increase astrocyte recruitment around plaques in amyloid‐bearing mice with coincident reductions in plaque size and number”

    Animalsin amyloid-bearing micehippocampus

    Modulation of Amyloid‐beta Metabolism by TIMP2 and MMP2 Through Extracellular Matrix Interactions in Mouse Models of Alzheimer's Pathology

    AAIC 2025 abstract23 Dec 2025

Theta oscillations

upin mice1

1 study

  1. Chondroitinase abc improves theta oscillations in mice.

    “Notably, selective degradation of PNNs in the dCA2 using chondroitinase ABC (ChABC) rescued recognition memory deficits and restored theta oscillations.”

    Animalsaccelerated mouse model of aginghippocampal dorsal CA2

    Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice

    Aging cell16 Jun 2025

Recognition memory

upin mice1

1 study

  1. Chondroitinase abc improves recognition memory in mice.

    “Notably, selective degradation of PNNs in the dCA2 using chondroitinase ABC (ChABC) rescued recognition memory deficits and restored theta oscillations.”

    Animalsaccelerated mouse model of aginghippocampal dorsal CA2

    Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice

    Aging cell16 Jun 2025

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