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Glucosamine + chondroitin sulfate + curcumin

Glucosamine + chondroitin sulfate + curcumin has been studied in 1 paper since 2016: 1 trial in people. The newest paper, Mar 3, 2016: “The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study”.

Intervention

1 paper studies it3 findingsUpdated

PubChemPubChemPubChemChEBIChEBI

“Treatment of knee OA with curcuminoids plus glycosaminoglycans, added to physical therapy, improves VAS at motion and Lequesne Index scores.”
The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled studyEuropean journal of physical and rehabilitation medicine2016

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Human trial1

What did studies of Glucosamine + chondroitin sulfate + curcumin find?

3

Studies of Glucosamine + chondroitin sulfate + curcumin measured 3 outcomes; the most studied are inflammation (1 study), Lequesne Index (1) and knee pain (1).

Inflammation

no changein humans1

1 study

  1. Glucosamine + chondroitin sulfate + curcumin has no effect on inflammation in humans.

    “No significant changes were found in the knee ROM and inflammation markers.”

    Human trialcombined with physical therapy in patients with knee osteoarthritis8 weeksn = 53

    The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study

    European journal of physical and rehabilitation medicine

More on Inflammation

Lequesne Index

downin humans1

1 study

  1. Glucosamine + chondroitin sulfate + curcumin decreases Lequesne Index in humans (F=7.091; P=0.009 at T2).

    “Lequesne Index showed reductions at T1 and T2 compared to T0 (F=9.535; P=0.0001), along with group effect, since the experimental group presented a lower score at T2 (F=7.091; P=0.009).”

    Human trialcombined with physical therapy in patients with knee osteoarthritis12 weeksn = 53

    The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study

    European journal of physical and rehabilitation medicine

More on Lequesne Index

Knee pain

downin humans1

1 study

  1. Glucosamine + chondroitin sulfate + curcumin decreases knee pain in humans.

    “Treatment of knee OA with curcuminoids plus glycosaminoglycans, added to physical therapy, improves VAS at motion and Lequesne Index scores.”

    Human trialcombined with physical therapy in patients with knee osteoarthritis8 weeksn = 53

    The efficacy and safety of a combination of glucosamine hydrochloride, chondroitin sulfate and bio-curcumin with exercise in the treatment of knee osteoarthritis: a randomized, double-blind, placebo-controlled study

    European journal of physical and rehabilitation medicine

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