Chaetoglobosin f

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Model organisms1

Outcomes

Aβ plaque accumulation

downin worms1

1 study

Chaetoglobosin f decreases Aβ plaque accumulation in worms.
“CF markedly reduced Aβ plaque accumulation, suppressed intracellular ROS levels, and promoted autophagosome formation.”
Model organismsin transgenic C. elegans expressing amyloid-beta
Chaetoglobosin F Attenuates Amyloid-β-Induced Neurotoxicity in Caenorhabditis elegans by Regulating Autophagy and Oxidative Stress Via the Insulin/IGF-1 and p38 MAPK Pathways
Neurochemical research20 Feb 2026

Chemotaxis

upin worms1

1 study

Chaetoglobosin f improves chemotaxis in worms.
“ameliorated Aβ-induced deficits in locomotion and chemotaxis.”
Model organismsin transgenic C. elegans expressing amyloid-beta
Chaetoglobosin F Attenuates Amyloid-β-Induced Neurotoxicity in Caenorhabditis elegans by Regulating Autophagy and Oxidative Stress Via the Insulin/IGF-1 and p38 MAPK Pathways
Neurochemical research20 Feb 2026

Locomotion

upin worms1

1 study

Chaetoglobosin f improves locomotion in worms.
“ameliorated Aβ-induced deficits in locomotion and chemotaxis.”
Model organismsin transgenic C. elegans expressing amyloid-beta
Chaetoglobosin F Attenuates Amyloid-β-Induced Neurotoxicity in Caenorhabditis elegans by Regulating Autophagy and Oxidative Stress Via the Insulin/IGF-1 and p38 MAPK Pathways
Neurochemical research20 Feb 2026

Paralysis

downin worms1

1 study

Chaetoglobosin f decreases paralysis in worms.
“treatment with CF significantly delayed paralysis”
Model organismsin transgenic C. elegans expressing amyloid-beta
Chaetoglobosin F Attenuates Amyloid-β-Induced Neurotoxicity in Caenorhabditis elegans by Regulating Autophagy and Oxidative Stress Via the Insulin/IGF-1 and p38 MAPK Pathways
Neurochemical research20 Feb 2026

Lifespan

upin worms1

1 study

Chaetoglobosin f extends lifespan in worms.
“treatment with CF significantly delayed paralysis, extended lifespan, and ameliorated Aβ-induced deficits in locomotion and chemotaxis.”
Model organismsin transgenic C. elegans expressing amyloid-beta
Chaetoglobosin F Attenuates Amyloid-β-Induced Neurotoxicity in Caenorhabditis elegans by Regulating Autophagy and Oxidative Stress Via the Insulin/IGF-1 and p38 MAPK Pathways
Neurochemical research20 Feb 2026

Latest

1 in 12 months

Neurochemical Research20 Feb