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cFLIP suppression

cFLIP suppression has been studied in 1 paper since 2022: none in people yet, 1 in animals. The research so far is in animals. The newest paper, Nov 22, 2022: “cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis”.

Intervention

1 paper studies it1 findingUpdated

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 2 countries
  • Animals1

What did studies of cFLIP suppression find?

1

Studies of cFLIP suppression measured 1 outcome; the most studied are cell killing (cytotoxicity) (1 study).

Cell killing (cytotoxicity)

upin cells1

1 study

  1. cFLIP suppression induces cell killing (cytotoxicity) in cells.

    “Activation of DR5 signaling by agonistic antibody, which can be enhanced further by suppression of cFLIP by BRD2 inhibition, leads to efficient killing of a variety of senescent cancer cells.”

    Cellsby BRD2 inhibition, in combination with DR5 agonistic antibody

    cFLIP suppression and DR5 activation sensitize senescent cancer cells to senolysis

    Nature cancer

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