Casein protein hydrolysate

1. Casein protein hydrolysate decreases FBXO32 in mouse cells (P = 0.004).

   “treating skeletal muscle cells with ex vivo human serum following feeding with a casein protein hydrolysate resulted in greater protein signaling, muscle protein synthesis, muscle growth, and lower expression of genes related to muscle protein breakdown”

   CellsC2C12 myotubes conditioned with human serum

   Comparative response of casein protein hydrolysate-fed young and older human serum on in vitro muscle protein metabolism and myotube size

   American journal of physiology. Cell physiology·13 Jan 2025

More on FBXO32

1. Casein protein hydrolysate increases myotube diameter in mouse cells (P = 0.049).

   “In addition, significant changes in myotube diameter (P = 0.049), atrogin-1 (P = 0.004), and MuRF-1 (P = 0.012) in response to CPH-fed compared with fasted serum were observed”

   CellsC2C12 myotubes conditioned with human serum

   Comparative response of casein protein hydrolysate-fed young and older human serum on in vitro muscle protein metabolism and myotube size

   American journal of physiology. Cell physiology·13 Jan 2025

1. Casein protein hydrolysate increases muscle protein synthesis in mouse cells (P = 0.041).

   “Analysis by two-way ANOVA of the fed relative to fasted MPS response revealed a main effect for protein type in pmTOR (P = 0.009), p70S6K (P = 0.031), p4E-BP1 (P = 0.047), and MPS (P = 0.041)”

   CellsC2C12 myotubes conditioned with human serum

   Comparative response of casein protein hydrolysate-fed young and older human serum on in vitro muscle protein metabolism and myotube size

   American journal of physiology. Cell physiology·13 Jan 2025