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Cardiosphere-derived cells

Intervention

1 paper6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab
  • Animals1

Outcomes

6

Telomere length

no changein mice1

1 study

  1. Cardiosphere-derived cells have no effect on telomere length in mice.

    “Finally, the telomere length was comparable between PBS- and CDC-injected mice.”

    Animalscompared with PBS injection

    Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts

    Circulation researchOct 26, 2018

More on Telomere length

Inflammation

no changein mice1

1 study

  1. Cardiosphere-derived cells have no effect on inflammation in mice.

    “The systemic aging performance measures, including exercise capacity, hair regrowth capacity, and inflammation, showed no significant improvement in CDC-injected mice.”

    Animalscompared with PBS injection

    Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts

    Circulation researchOct 26, 2018

More on Inflammation

Exercise capacity

no changein mice1

1 study

  1. Cardiosphere-derived cells have no effect on exercise capacity in mice.

    “The systemic aging performance measures, including exercise capacity, hair regrowth capacity, and inflammation, showed no significant improvement in CDC-injected mice.”

    Animalscompared with PBS injection

    Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts

    Circulation researchOct 26, 2018

Cardiac fibrosis

no changein mice1

1 study

  1. Cardiosphere-derived cells have no effect on cardiac fibrosis in mice.

    “Postmortem analysis of aging mouse hearts showed similar fibrotic degree in the 2 groups.”

    Animalscompared with PBS injectionheart

    Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts

    Circulation researchOct 26, 2018

Left ventricular diastolic wall thickness

upin mice1

1 study

  1. Cardiosphere-derived cells increase left ventricular diastolic wall thickness in mice.

    “The diastolic wall thickness of LV was significantly increased after CDC injection, resulting in reduced diastolic LV volume.”

    Animalscompared with PBS injectionheart

    Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts

    Circulation researchOct 26, 2018

Cardiac function

no changein mice1

1 study

  1. Cardiosphere-derived cells have no effect on cardiac function in mice.

    “these results indicate that CDCs do not improve heart function and systemic performances in aging mice.”

    Animalscompared with PBS injectionheart

    Lack of Cardiac Improvement After Cardiosphere-Derived Cell Transplantation in Aging Mouse Hearts

    Circulation researchOct 26, 2018

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