Cancer cell secretome

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 2 countries

Funder: European Commission

Cells1

Outcomes

MSC spreading area

downin human cells1

1 study

Cancer cell secretome decreases MSC spreading area in human cells (~2100 μm2 compared to the control ~2500 μm2).
“Tumor con-ditioned media also reduced MSC spreading area (~2100 μm2 compared to the control ~2500 μm2)”
Cellsexposure to RPMI 8226 or HG-3 cancer cell secretomes
Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated Phenotype
Preprints.org18 Mar 2026Preprint

Cellular senescence

upin human cells1

1 study

Cancer cell secretome induces cellular senescence in human cells (~3-4x higher than that of the control).
“induced senescence (~3-4x higher than that of the control)”
Cellsexposure to RPMI 8226 or HG-3 cancer cell secretomes
Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated Phenotype
Preprints.org18 Mar 2026Preprint

Latest

1 in 12 months

Preprints.org18 Mar

Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated Phenotype

Preprint: experiments in human cellsExtracellular matrix remodelling

Paper

Cancer cell secretome

Outcomes

Latest

Paracrine Signals from the Tumor Microenvironment Modulate Stem-Cell Collagen Interaction, Remodeling and Reprogramming Toward a Cancer-Associated Phenotype

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