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Caloric restriction + time-restricted feeding

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab
  • Animals1

Outcomes

5

Water intake

downin rats1

1 study

  1. Caloric restriction + time-restricted feeding decreases water intake in rats.

    “both interventions markedly reduced water intake”

    Animalsin streptozotocin-induced diabetic rats

    Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats

    Frontiers in physiology21 Aug 2025

More on Water intake

Body weight

no changein rats1

1 study

  1. Caloric restriction + time-restricted feeding has no effect on body weight in rats.

    “Although CR-TRF did not significantly improve body weight”

    Animalsin streptozotocin-induced diabetic rats

    Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats

    Frontiers in physiology21 Aug 2025

Renal damage

downin rats1

1 study

  1. Caloric restriction + time-restricted feeding decreases renal damage in rats.

    “Diabetic rats exhibited liver and renal damage, which were significantly attenuated by CR-TRF.”

    Animalsin streptozotocin-induced diabetic ratskidney

    Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats

    Frontiers in physiology21 Aug 2025

Liver damage

downin rats1

1 study

  1. Caloric restriction + time-restricted feeding decreases liver damage in rats.

    “Diabetic rats exhibited liver and renal damage, which were significantly attenuated by CR-TRF.”

    Animalsin streptozotocin-induced diabetic ratsliver

    Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats

    Frontiers in physiology21 Aug 2025

Hepatomegaly

downin rats1

1 study

  1. Caloric restriction + time-restricted feeding protects against hepatomegaly in rats.

    “both interventions markedly reduced water intake and improved hepatomegaly.”

    Animalsin streptozotocin-induced diabetic ratsmales

    Calorie and time-restricted feeding improves liver and kidney histopathology in streptozotocin-induced type 1 diabetic rats

    Frontiers in physiology21 Aug 2025

More on Hepatomegaly

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