Resistance training + caloric restriction

2 papers6 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 2 countries

Funder: Melanoma Centre of Research Excellence

Animals1

Outcomes

6

ATGL mRNA

upin rats1

1 study

Resistance training + caloric restriction increases ATGL mRNA in rats.
“significantly upregulating ATGL, AMPK, SIRT1, and PGC-1α compared to HFD (all p < 0.05).”
Animalsdiet-induced obesity (HFD)skeletal muscle8 weeksmales
Impact of Caloric Restriction and Resistance Training on Weight Management, Insulin Sensitivity, and Adipose Tissue Protein Dynamics
Oxidative medicine and cellular longevity6 Feb 2026

More on ATGL mRNA

Perilipin 1 mRNA

downin rats1

1 study

Resistance training + caloric restriction decreases perilipin 1 mRNA in rats.
“At the molecular level, CR + RT downregulated perilipin 1 and FSP-27”
Animalsdiet-induced obesity (HFD)8 weeksmales
Impact of Caloric Restriction and Resistance Training on Weight Management, Insulin Sensitivity, and Adipose Tissue Protein Dynamics
Oxidative medicine and cellular longevity6 Feb 2026

More on Perilipin 1 mRNA

HOMA-IR

downin rats1

1 study

Resistance training + caloric restriction decreases HOMA-IR in rats (1.24 ± 0.05 vs 5.55 ± 0.21).
“CR + RT group demonstrated the lowest value (1.24 ± 0.05), comparable to the normal diet group (p > 0.05).”
Animalsdiet-induced obesity (HFD)8 weeksmales
Impact of Caloric Restriction and Resistance Training on Weight Management, Insulin Sensitivity, and Adipose Tissue Protein Dynamics
Oxidative medicine and cellular longevity6 Feb 2026

More on HOMA-IR

Body weight

downin rats1

1 study

Resistance training + caloric restriction decreases body weight in rats (292.2 ± 1.8 g vs 509.8 ± 6.0 g).
“rats in HFD group exhibited the highest body weight (509.8 ± 6.0g), whereas CR + RT group showed the most pronounced reduction (292.2 ± 1.8 g; p < 0.001).”
Animalsdiet-induced obesity (HFD)8 weeksmales
Impact of Caloric Restriction and Resistance Training on Weight Management, Insulin Sensitivity, and Adipose Tissue Protein Dynamics
Oxidative medicine and cellular longevity6 Feb 2026

Whole-body fat mass

downin humans1

1 study

Resistance training + caloric restriction decreases whole-body fat mass in humans (ES = -5.3 kg, 95% CI: -7.2 to -3.5 kg, p < 0.001).
“whole-body fat mass (ES = -5.3 kg, 95% CI: -7.2 to -3.5 kg, p < 0.001) compared with groups without intervention.”
Reviewcompared with groups without intervention
Resistance training effectiveness on body composition and body weight outcomes in individuals with overweight and obesity across the lifespan: A systematic review and meta-analysis
Obesity reviews : an official journal of the International Association for the Study of Obesity21 Feb 2022

Body fat percentage

downin humans1

1 study

Resistance training + caloric restriction decreases body fat percentage in humans (ES = -3.8%, 95% CI: -4.7 to -2.9%, p < 0.001).
“Interventions involving resistance training and caloric restriction were the most effective for reducing body fat percentage (ES = -3.8%, 95% CI: -4.7 to -2.9%, p < 0.001)”
Reviewcompared with groups without intervention
Resistance training effectiveness on body composition and body weight outcomes in individuals with overweight and obesity across the lifespan: A systematic review and meta-analysis
Obesity reviews : an official journal of the International Association for the Study of Obesity21 Feb 2022

Latest

1 in 12 months

Oxidative Medicine and Cellular Longevity9 Feb

Impact of Caloric Restriction and Resistance Training on Weight Management, Insulin Sensitivity, and Adipose Tissue Protein Dynamics

Experiments in 50 ratsDietary restriction

Obesity Reviews21 Feb

Resistance training effectiveness on body composition and body weight outcomes in individuals with overweight and obesity across the lifespan: A systematic review and meta-analysis

Meta-analysis of randomised trialsCombined aerobic and resistance training