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Calcium carbonate nanoparticles

Intervention

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • Funder: National Natural Science Foundation of China
  • Animals1

Outcomes

4

Osteoblast mineralization

upin cells1

1 study

  1. Calcium carbonate nanoparticles increase osteoblast mineralization in cells.

    “Simultaneously, through calcium supplementation, the nanoparticle promotes osteoblast differentiation and mineralization.”

    Cellsthrough calcium supplementationcomplexed with nicotinamide mononucleotideosteoblast

    Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis

    Advanced healthcare materials15 Jul 2025

Osteoblast differentiation

upin cells1

1 study

  1. Calcium carbonate nanoparticles increase osteoblast differentiation in cells.

    “Simultaneously, through calcium supplementation, the nanoparticle promotes osteoblast differentiation and mineralization.”

    Cellsthrough calcium supplementationcomplexed with nicotinamide mononucleotideosteoblast

    Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis

    Advanced healthcare materials15 Jul 2025

Osteoblast osteogenic function

upin cells1

1 study

  1. Calcium carbonate nanoparticles improve osteoblast osteogenic function in cells.

    “This nanoparticle facilitates the complexation of nicotinamide mononucleotide, enabling targeted delivery to osteoblasts, reversing osteoblast senescence, and restoring their osteogenic function.”

    Cellscomplexed with nicotinamide mononucleotideosteoblast

    Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis

    Advanced healthcare materials15 Jul 2025

Cellular senescence

downin cells1

1 study

  1. Calcium carbonate nanoparticles decrease cellular senescence in cells.

    “This nanoparticle facilitates the complexation of nicotinamide mononucleotide, enabling targeted delivery to osteoblasts, reversing osteoblast senescence, and restoring their osteogenic function.”

    Cellscomplexed with nicotinamide mononucleotideosteoblast

    Dual-Functional Nanoparticles to Reverse Osteoblast Senescence and Enhance Calcium Supplementation for Alleviating Senile Osteoporosis

    Advanced healthcare materials15 Jul 2025

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