Tumor incidence
upin rats1
Bromodeoxyuridine increases tumor incidence in rats.
“is followed by a dose-related increase in tumor incidence.”
Animals
Mutation research1 Mar 1992
Chromosome aberration incidence
upin rats1
Bromodeoxyuridine increases chromosome aberration incidence in rats (2-fold incidence).
“neonatal administration of BrdUrd to rats doubles the incidence of chromosome aberrations in peripheral blood lymphocytes in comparison to controls”
Animalscompared with controlsperipheral blood lymphocyte
Mutation research1 Mar 1992
Reproductive system function
downin rats1
Bromodeoxyuridine impairs reproductive system function in rats.
“age-related changes in the length of the estrous cycle and in the incidence of persistent estrus and/or anestrus were observed earlier in BrdUrd-injected female rats”
Animalscompared with untreated ratsreproductive systemfemales
Mutation research1 Mar 1992
Lifespan
downin rats1
Bromodeoxyuridine shortens lifespan in rats (−31% with 2 injections; −38% with 4 injections).
“The mean life span decreased by 31% and 38% in male and by 14% and 27% in female rats”
Animalscompared with untreated controls3.2 mg per injection; 2 or 4 injectionspostnatal days 1 and 3, or 1, 3, 7 and 21males
Mutation research1 Mar 1992
1 trialPhase 275 people
An experiment in twelve-month-old mice found better learning and memory alongside more immature nerve cells and greater insulation around nerve fibres.An experiment in twelve-month-old mice found better learning and memory alongside more immature nerve cells and greater insulation around nerve fibres.