Borrelidin

1 paper1 finding

1 lab in 1 country

Funders: Royal Society and 1 more

Model organisms1

Outcomes

1

Lifespan

downin flies1

1 study

Borrelidin shortens lifespan in flies.
“Borrelidin, a tRNA synthetase inhibitor, significantly reduced lifespan in a both dATF4 and diet-dependent manner, independent of microbial load”
Model organismsdATF4- and diet-dependent; independent of microbial load
Suppression rather than activation of the integrated stress response (GCN2-ATF4) pathway extends lifespan in the fly
Proceedings of the National Academy of Sciences of the United States of America28 Apr 2026

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