Bms 182874

1. Bms 182874 decreases systolic blood pressure in rats (p < 0.05).

   “BMS had no effect on SBP in females and a small, but significant (p < 0.05), SBP-lowering effect in males.”

   Animalssalt-loaded stroke-prone spontaneously hypertensive rats40 mg/kg/daymales

   Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats

   Journal of cardiovascular pharmacology·1 Nov 2000

More on Systolic blood pressure

1. Bms 182874 decreases proteinuria in rats (13 +/- 0.5 vs 161 +/- 1.3 mg/day at 16 weeks).

   “In the treated group, development of proteinuria was significantly delayed (13 +/- 0.5 mg/day at 16 weeks).”

   Animalssalt-loaded stroke-prone spontaneously hypertensive ratskidney40 mg/kg/day16 weeks

   Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats

   Journal of cardiovascular pharmacology·1 Nov 2000

More on Proteinuria

1. Bms 182874 extends lifespan in rats (223 days vs 136 days (p <0.01)).

   “Treatment with BMS increased survival to 223 days in males (range 129-280 days, p <0.01 vs controls)”

   Animalssalt-loaded stroke-prone spontaneously hypertensive ratsmixed in the food40 mg/kg/daymalesn = 6

   Endothelin-A-receptor blockade improves renal function and doubles the lifespan of stroke-prone spontaneously hypertensive rats

   Journal of cardiovascular pharmacology·1 Nov 2000