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Blood-brain barrier-permeable macrocyclic chimeras

Blood-brain barrier-permeable macrocyclic chimeras has been studied in 1 paper since 2026: none in people yet, 1 in animals; 1 in the past year. The research so far is in animals. The newest story, Oct 27, 2026: “Compounds broke down an activated brain protein in aged mice”.

Intervention

1 paper studies it3 findingsUpdated

More peptides

1 new paper in 30 daysSee all 1

None of its findings points the other way.

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 1 more
  • Animals1

What did studies of Blood-brain barrier-permeable macrocyclic chimeras find?

3

Studies of Blood-brain barrier-permeable macrocyclic chimeras measured 3 outcomes; the most studied are cognitive function (1 study), amyloid-beta deposition (1) and ACTIVATEDDAPK1 (1).

Cognitive function

upin mice1

1 study

  1. Blood-brain barrier-permeable macrocyclic chimeras improve cognitive function in mice.

    “Systemic administration of BmTACs in aged APP/PS1 mice achieved potent degradation of activated DAPK1, attenuated amyloid-β deposition and Tau hyperphosphorylation, and improved cognition.”

    AnimalsAPP/PS1 mice

    Compounds broke down an activated brain protein in aged mice

    Journal of the American Chemical Society

Amyloid-beta deposition

downin mice1

1 study

  1. Blood-brain barrier-permeable macrocyclic chimeras decrease amyloid-beta deposition in mice.

    “Systemic administration of BmTACs in aged APP/PS1 mice achieved potent degradation of activated DAPK1, attenuated amyloid-β deposition and Tau hyperphosphorylation, and improved cognition.”

    AnimalsAPP/PS1 micebrain

    Compounds broke down an activated brain protein in aged mice

    Journal of the American Chemical Society

More on Amyloid-beta deposition

ACTIVATEDDAPK1

downin mice1

1 study

  1. Blood-brain barrier-permeable macrocyclic chimeras decrease ACTIVATEDDAPK1 in mice.

    “Systemic administration of BmTACs in aged APP/PS1 mice achieved potent degradation of activated DAPK1”

    AnimalsAPP/PS1 micebrain

    Compounds broke down an activated brain protein in aged mice

    Journal of the American Chemical Society

More on ACTIVATEDDAPK1

Latest

Nov 2025: 0Dec 2025: 0Jan 2026: 0Feb 2026: 0Mar 2026: 0Apr 2026: 0May 2026: 0Jun 2026: 0Jul 2026: 0Aug 2026: 0Sep 2026: 1Oct 2026: 01 paper in 12 months
Journal of the American Chemical Society

Compounds broke down an activated brain protein in aged mice

Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.

Mouse studyInterventions
Paper

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