ACTIVATEDDAPK1

Gene

1 paper studies it1 finding

1 new paper in 30 daysSee all 1

  • 1 lab in 1 country
  • Funders: Fundamental Research Funds for the Central Universities and 1 more
  • Animals1

Interventions

1

Blood-brain barrier-permeable macrocyclic chimeras

downin mice1

1 study
  1. Blood-brain barrier-permeable macrocyclic chimeras decrease ACTIVATEDDAPK1 in mice.

    “Systemic administration of BmTACs in aged APP/PS1 mice achieved potent degradation of activated DAPK1”

    AnimalsAPP/PS1 micebrain

    Compounds broke down an activated brain protein in aged mice

    Journal of the American Chemical Society

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Journal of the American Chemical Society

Compounds broke down an activated brain protein in aged mice

Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.

Mouse studyInterventions