Blood-brain barrier-permeable macrocyclic chimeras

Papers on blood-brain barrier-permeable macrocyclic chimeras

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Tuesday, October 27

Journal of the American Chemical Society

Compounds broke down an activated brain protein in aged mice

Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.Bloodstream delivery in aged Alzheimer's-model mice also reduced amyloid deposits and abnormal changes to tau protein, and improved cognition.

A large neuron with sparse deposits sits beside a smaller neuron crowded with deposits, with a laboratory mouse, molecular ring, and protein fragments below.
Mouse studyInterventions