Bioengineered tracheal grafts

1 paper2 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Funder: National Natural Science Foundation of China

Animals1

Associations

Survival

upin O. cuniculus1upin pigs1

1 study

Bioengineered tracheal grafts are associated with survival in pigs (Survival for up to 115 days; species-specific duration not reported).
“in rabbit and porcine models, these bioengineered grafts maintain airway patency and support preclinical animal survival for up to 115 days.”
AnimalsOrthotopic transplantation for segmental tracheal defectsThree-dimensional printed porous minichannel scaffolds filled with cartilage granules, platelet-rich plasma, and adipose-derived stem cellstracheaUp to 115 days
3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models
Nature communications11 Sep 2026
Bioengineered tracheal grafts are associated with survival in O. cuniculus (Survival for up to 115 days; species-specific duration not reported).
“in rabbit and porcine models, these bioengineered grafts maintain airway patency and support preclinical animal survival for up to 115 days.”
AnimalsOrthotopic transplantation for segmental tracheal defectsThree-dimensional printed porous minichannel scaffolds filled with cartilage granules, platelet-rich plasma, and adipose-derived stem cellstracheaUp to 115 days
3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models
Nature communications11 Sep 2026

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Nature CommunicationsYesterday

3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models

Experiments in rabbitsBones and joints

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Bioengineered tracheal grafts

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3D minichannel-morphed adipose stem cell-cartilage granule reconstituted tough grafts for repairing segmental tracheal defects in preclinical models

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