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Bakuchiol

Intervention

3 papers study it1 more mentions it10 findings

PubChemMeSH

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

  • 3 independent labs in 2 countries
  • 1 finding against
  • Funders: Department of Science and Technology-Cognition Science Research Initiative and 4 more
  • Model organisms3

Outcomes

8

Lifespan

upin worms2no changein Caenorhabditis1

3 studies

  1. Bakuchiol extends lifespan in worms.

    “Bakuchiol at an optimal concentration of 37.5 μM meaningfully extends lifespan”

    Model organisms37.5 μM

    Natural anti-aging innovations: Bakuchiol role in longevity and stress resilience through DAF-16 pathway activation

    Biochemical and biophysical research communicationsMay 2, 2025

  2. Bakuchiol has no effect on lifespan in Caenorhabditis.

    “Both tamibarotene, a potent RAR agonist, and bakuchiol, a meroterpene derived from Psoralea corylifolia , showed no significant increase in lifespan across a dosage range of six concentrations.”

    Model organisms

    Caenorhabditis Intervention Testing Program: all-trans retinoic acid-related compounds tamibarotene and bakuchiol do not extend lifespan in Caenorhabditis nematodes

    microPublication biologyFeb 12, 2025

  3. Bakuchiol extends lifespan in worms.

    “Bakuchiol demonstrated significant elevation of ACh transmission, reduction of reactive oxygen species (ROS) levels, and extension of lifespan.”

    Model organisms

    Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity

    Natural product researchOct 19, 2023

sod-3

upin worms1

1 study

  1. Bakuchiol increases sod-3 in worms.

    “boosts the activity of superoxide dismutase (SOD-3)”

    Model organisms

    Natural anti-aging innovations: Bakuchiol role in longevity and stress resilience through DAF-16 pathway activation

    Biochemical and biophysical research communicationsMay 2, 2025

More on sod-3

FOXO signaling

upin worms1

1 study

  1. Bakuchiol activates FOXO signaling in worms.

    “Bakuchiol promotes the nuclear translocation of DAF-16”

    Model organisms

    Natural anti-aging innovations: Bakuchiol role in longevity and stress resilience through DAF-16 pathway activation

    Biochemical and biophysical research communicationsMay 2, 2025

More on FOXO signaling

Toxicity

upin Caenorhabditis1

1 study

  1. Bakuchiol induces toxicity in Caenorhabditis.

    “Additionally, bakuchiol was broadly toxic at higher doses.”

    Model organismsat higher doses

    Caenorhabditis Intervention Testing Program: all-trans retinoic acid-related compounds tamibarotene and bakuchiol do not extend lifespan in Caenorhabditis nematodes

    microPublication biologyFeb 12, 2025

Lipids

downin worms1

1 study

  1. Bakuchiol decreases lipids in worms.

    “Bakuchiol showed efficacy in reducing amyloid β and lipid levels”

    Model organisms

    Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity

    Natural product researchOct 19, 2023

More on Lipids

Amyloid-beta

downin worms1

1 study

  1. Bakuchiol decreases amyloid-beta in worms.

    “Bakuchiol showed efficacy in reducing amyloid β and lipid levels”

    Model organisms

    Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity

    Natural product researchOct 19, 2023

More on Amyloid-beta

Synaptic transmission

upin worms1

1 study

  1. Bakuchiol increases synaptic transmission in worms.

    “Bakuchiol demonstrated significant elevation of ACh transmission, reduction of reactive oxygen species (ROS) levels, and extension of lifespan.”

    Model organisms

    Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity

    Natural product researchOct 19, 2023

More on Synaptic transmission

Reactive oxygen species

downin worms1

1 study

  1. Bakuchiol decreases reactive oxygen species in worms.

    “Bakuchiol demonstrated significant elevation of ACh transmission, reduction of reactive oxygen species (ROS) levels, and extension of lifespan.”

    Model organisms

    Bakuchiol modulates acetylcholine synthesis and alleviates Aβ proteotoxicity

    Natural product researchOct 19, 2023

More on Reactive oxygen species

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