Astrocyte-derived extracellular vesicles
1 paper3 findings
- 1 lab in 1 country
- Funders: Defense Technical Information Center and 3 more
- Animals1
Outcomes
3Amyloid plaque burden
no changein mice1
1 study
Amyloid plaque burden
no changein mice1
Astrocyte-derived extracellular vesicles have no effect on amyloid plaque burden in mice.
“No overt changes were observed in the staining of amyloid plaque burden (6E10), and astrogliosis (GFAP).”
Animalsin female PSAPP micebrain6 monthsfemales
Experimental neurology3 Jul 2026
MAPT
upin mice1
1 study
MAPT
upin mice1
Astrocyte-derived extracellular vesicles increase MAPT in mice.
“increased cortical tau accumulation was observed in MCI- and AD-AEV injected mice”
Animalsin female PSAPP micecortex6 monthsfemales
Experimental neurology3 Jul 2026
Motor coordination
downin mice1
1 study
Motor coordination
downin mice1
Astrocyte-derived extracellular vesicles impair motor coordination in mice (p < 0.0001).
“Rotarod assessment revealed significant impairment in motor coordination (p < 0.0001) in mice receiving MCI- and AD-AEVs compared with those receiving CNC-AEVs.”
Animalsin female PSAPP micebrain6 monthsfemales
Experimental neurology3 Jul 2026
Latest
1 in 12 monthsExperimental Neurology
Neuropathological and functional impact of astrocyte-derived extracellular vesicles in an aged model of Alzheimer's disease
Experiments in miceMechanisms