Arteriovenous fistula creation

1 paper4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Cardiomyocyte cross-sectional area

upin pigs1

1 study

Arteriovenous fistula creation increases cardiomyocyte cross-sectional area in pigs (from 800.9 μm 2 to 1250.0 μm 2 , p=0.0296).
“Cardiomyocyte cross-sectional area was increased (from 800.9 μm 2 to 1250.0 μm 2 , p=0.0296)”
Animalsin uremic pigs with AVF supported by PTAleft ventricle42 days post-PTA
Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model
AHA Scientific Sessions 2025 abstract3 Nov 2025

Left ventricular end-diastolic volume

upin pigs1

1 study

Arteriovenous fistula creation increases left ventricular end-diastolic volume in pigs (200.8ml to 249.5ml, p=0.0457).
“Increased end-diastolic volumes were observed in the left and right ventricles at day 42 vs 14 (200.8ml to 249.5ml, p=0.0457, and 204.6ml to 260.0ml, p=0.0268 respectively)”
Animalsin uremic pigs with AVF supported by PTAleft ventricle42 days post-PTA
Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model
AHA Scientific Sessions 2025 abstract3 Nov 2025

More on Left ventricular end-diastolic volume

CDKN2A

upin pigs1

1 study

Arteriovenous fistula creation increases CDKN2A in pigs (fold change 10.21, p=0.0086).
“In perivascular areas of the free wall of the LV at day 42 vs control, senescence markers showed increased p16 expression (fold change 10.21, p=0.0086)”
Animalsin uremic pigs with AVF supported by PTAleft ventricle42 days post-PTA
Arteriovenous fistula creation results in cardiac dysfunction and remodeling in a uremic pig model
AHA Scientific Sessions 2025 abstract3 Nov 2025

Latest

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AHA Scientific Sessions 2025 Abstract3 Nov