APX-115
- 1 lab in 1 country
- Funders: Korea Health Industry Development Institute and 2 more
- Animals1
Outcomes
5KL
upin mice1
1 study
KL
upin mice1
APX-115 increases KL in mice.
“Klotho expression was significantly decreased in diabetic aging kidneys, and APX-115 restored Klotho level.”
Animalsdiabetic aging micekidney60 mg/kg/day12 weeks
Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
Kidney research and clinical practice
Albuminuria
no changein mice1
1 study
Albuminuria
no changein mice1
APX-115 has no effect on albuminuria in mice.
“Although APX-115 did not significantly decrease albuminuria”
Animalsdiabetic aging miceurine60 mg/kg/day12 weeks
Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
Kidney research and clinical practice
Mesangial expansion
downin mice1
1 study
Mesangial expansion
downin mice1
APX-115 decreases mesangial expansion in mice.
“APX-115 markedly improved mesangial expansion”
Animalsdiabetic aging micekidney60 mg/kg/day12 weeks
Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
Kidney research and clinical practice
8-isoprostane
downin mice1
1 study
8-isoprostane
downin mice1
APX-115 decreases 8-isoprostane in mice.
“APX-115 treatment reduced 8-isoprostane level.”
Animalsdiabetic aging miceurine60 mg/kg/day12 weeks
Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
Kidney research and clinical practice
Insulin resistance
downin mice1
1 study
Insulin resistance
downin mice1
APX-115 decreases insulin resistance in mice.
“APX-115 significantly improved insulin resistance in diabetic aging mice.”
Animalsdiabetic aging mice60 mg/kg/day12 weeks
Pan-Nox inhibitor treatment improves renal function in aging murine diabetic kidneys
Kidney research and clinical practice