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Appa

Intervention

1 paper studies it5 findings

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Against: findings that point the other way from most findings on the same outcome.

  • 1 lab in 1 country
  • 1 finding against
  • Funder: National Institutes of Health
  • Model organisms1

Outcomes

4

Lifespan

no changein worms1upin worms1

1 study

  1. Appa has no effect on lifespan in worms.

    “the APPA's life-prolonging effects were absent on the daf-2, daf-16, skn-1, and hsf-1 mutants”

    Model organismsin daf-2, daf-16, skn-1, and hsf-1 mutants

    APPA Increases Lifespan and Stress Resistance via Lipid Metabolism and Insulin/IGF-1 Signal Pathway in Caenorhabditis elegans

    International journal of molecular sciences

  2. Appa extends lifespan in worms.

    “APPA increases C. elegans' longevity without affecting the typical metabolism of Escherichia coli OP50”

    Model organisms

    APPA Increases Lifespan and Stress Resistance via Lipid Metabolism and Insulin/IGF-1 Signal Pathway in Caenorhabditis elegans

    International journal of molecular sciences

Healthspan

upin worms1

1 study

  1. Appa improves healthspan in worms.

    “increased anti-stress capacity”

    Model organisms

    APPA Increases Lifespan and Stress Resistance via Lipid Metabolism and Insulin/IGF-1 Signal Pathway in Caenorhabditis elegans

    International journal of molecular sciences

Oxidative stress and ROS signaling

downin worms1

1 study

  1. Appa decreases oxidative stress and ROS signaling in worms.

    “decreased the levels of reactive oxygen species, lipofuscin, and fat”

    Model organisms

    APPA Increases Lifespan and Stress Resistance via Lipid Metabolism and Insulin/IGF-1 Signal Pathway in Caenorhabditis elegans

    International journal of molecular sciences

More on Oxidative stress and ROS signaling

Physical function

upin worms1

1 study

  1. Appa improves physical function in worms.

    “increased locomotor ability”

    Model organisms

    APPA Increases Lifespan and Stress Resistance via Lipid Metabolism and Insulin/IGF-1 Signal Pathway in Caenorhabditis elegans

    International journal of molecular sciences

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