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Ap@abt263

Intervention

1 paper studies it4 findings

Across all fields, 1 paper: none in people yet, 1 in animals

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Funders: Basic and Applied Basic Research Foundation of Guangdong Province and 4 more
  • Animals1

Outcomes

4

Adverse cardiac remodeling

downin animals1

1 study

  1. Ap@abt263 prevents adverse cardiac remodeling.

    “preventing adverse cardiac remodeling”

    Animalsin vivo

    Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure

    ACS applied materials & interfaces

Senescence-associated secretory phenotype (SASP)

downin animals1

1 study

  1. Ap@abt263 decreases senescence-associated secretory phenotype (SASP).

    “attenuated the deleterious effects of SASP”

    Animalsin vivo

    Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure

    ACS applied materials & interfaces

More on Senescence-associated secretory phenotype (SASP)

Cardiac function

upin animals1

1 study

  1. Ap@abt263 improves cardiac function.

    “enhanced cardiac function”

    Animalsin vivo

    Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure

    ACS applied materials & interfaces

Cellular senescence

downin animals1

1 study

  1. Ap@abt263 decreases cellular senescence.

    “AP@ABT263 efficiently eradicated senescent cardiomyocytes”

    Animalsin vitro and in vivo

    Peptide-Amphiphilic Nanoassemblies as a Responsive Senolytic Navigator for Targeted Removal of Senescent Cardiomyocytes to Ameliorate Heart Failure

    ACS applied materials & interfaces

More on Cellular senescence

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