Antimicrobial peptides

Antimicrobial peptides impair locomotor function in flies.

“AMP binding occurs in a PS-dependent manner, leading to synaptic bouton fragmentation, accelerated neuronal aging, and locomotor decline.”

Model organismsphosphatidylserine-dependent AMP binding

The phosphatidylserine-binding proteins Turandots protect the peripheral nervous system from antimicrobial peptide toxicity

bioRxiv (Cold Spring Harbor Laboratory)·4 May 2026Preprint

Antimicrobial peptides increase synaptic bouton fragmentation in flies.

“AMP binding occurs in a PS-dependent manner, leading to synaptic bouton fragmentation, accelerated neuronal aging, and locomotor decline.”

Model organismsphosphatidylserine-dependent AMP bindingmotoneuron

The phosphatidylserine-binding proteins Turandots protect the peripheral nervous system from antimicrobial peptide toxicity

bioRxiv (Cold Spring Harbor Laboratory)·4 May 2026Preprint

Antimicrobial peptides increase motoneuron damage in flies.

“We show that cationic AMPs selectively bind and damage motoneurons that expose phosphatidylserine (PS)”

Model organismsneuronal phosphatidylserine exposurecationicmotoneuron

The phosphatidylserine-binding proteins Turandots protect the peripheral nervous system from antimicrobial peptide toxicity

bioRxiv (Cold Spring Harbor Laboratory)·4 May 2026Preprint