Anti-upar car t cells

1 paper3 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

1 lab in 1 country

Animals1

Outcomes

Inflammation

downin mice1

1 study

Anti-upar car t cells decrease inflammation in mice.
“both therapeutic and prophylactic treatment with anti-uPAR CAR T cells improved barrier function, regenerative capacity, inflammation, mucosal immune function and microbiome composition in aged mice”
Animalsagingintestine
Anti-uPAR CAR T cells reverse and prevent aging-associated defects in intestinal regeneration and fitness
Nature aging25 Nov 2025

Latest

1 in 12 months

Nature Aging26 Nov