Annual wellness visit

3 papers4 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Labs are independent when their papers share no last author and no institution.

Against: findings that point the other way from most findings on the same outcome.

On aging: the drug’s trials ARN judged to be about aging, of every trial that tests it for any use.

No results posted: trials that ended more than a year ago with no results on ClinicalTrials.gov and no paper in ARN’s record.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

2 independent labs in 1 country

Human trial1
Humans1

Outcomes

Fear of falling

downin humans1

1 study

Annual wellness visit decreases fear of falling in humans.
“There was a decrease in the percentage of residents that worried about falling, were smoking, not exercising, or did not have an advanced directive.”
Human trialfemale and malesn = 105
Changing Health Behaviors Using Annual Wellness Visits Among Senior Housing Residents
GSA 2025 abstract31 Dec 2025

Smoking

downin humans1

1 study

Annual wellness visit decreases smoking in humans.
“There was a decrease in the percentage of residents that worried about falling, were smoking, not exercising, or did not have an advanced directive.”
Human trialfemale and malesn = 105
Changing Health Behaviors Using Annual Wellness Visits Among Senior Housing Residents
GSA 2025 abstract31 Dec 2025

Associations

Alzheimer's disease and related dementias

no changein humans1HR 1.23

1 study

Annual wellness visit is associated with Alzheimer's disease and related dementias in humans (HR 1.23, 95% CI 0.91–1.66).
“insignificantly associated with increase in ADRD diagnosis (HR: 1.23, 95% CI: 0.91‐ 1.66).”
Humanswithin 2 years after AWV
Annual Wellness Visits, Cognitive Function, and Early Dementia Diagnosis ‐ Analysis of the Health Retirement Study linked to Medicare Data
AAIC 2025 abstract23 Dec 2025

More on Alzheimer's disease and related dementias

Mild cognitive impairment

upin humans1HR 1.79

1 study

Annual wellness visit raises the risk of mild cognitive impairment in humans (HR 1.79, 95% CI 1.10–2.91).
“AWV visit was significantly associated with increase in MCI diagnosis (HR: 1.79, 95% CI: 1.10 – 2.91)”
Humanswithin 2 years after AWV
Annual Wellness Visits, Cognitive Function, and Early Dementia Diagnosis ‐ Analysis of the Health Retirement Study linked to Medicare Data
AAIC 2025 abstract23 Dec 2025