Ampicillin

Ampicillin impairs fitness in mice.

“Adult ELA-treated males had reduced fitness under free-fed conditions — driven by smaller body size, fat stores, and impaired immunity”

Animalsunder free-fed conditionsmales

Early-life microbiota disruption by antibiotics elicits fitness trade-offs that differ by sex

bioRxiv (Cold Spring Harbor Laboratory)·Aug 27, 2025Preprint

Ampicillin decreases energy expenditure in mice.

“treating young mice with high– or low-dose ampicillin altered the gut microbiome and elicited reduced lean mass and energy expenditure in males”

Animalsyoung micemales

Early-life microbiota disruption by antibiotics elicits fitness trade-offs that differ by sex

bioRxiv (Cold Spring Harbor Laboratory)·Aug 27, 2025Preprint

Ampicillin increases visceral adiposity in mice.

“treating young mice with high– or low-dose ampicillin altered the gut microbiome and elicited reduced lean mass and energy expenditure in males to promote increased adult visceral adiposity.”

Animalsyoung micemales

Early-life microbiota disruption by antibiotics elicits fitness trade-offs that differ by sex

bioRxiv (Cold Spring Harbor Laboratory)·Aug 27, 2025Preprint

Ampicillin decreases cell viability in flies.

“Moreover, AMP-treated flies showed decreased cell viability in ovary and testis, leading to impaired reproductive function.”

Model organismsovary and testis

Evaluating the potential toxicity of ampicillin using Drosophila melanogaster as a model organism

Toxicology reports·Mar 11, 2025

Ampicillin decreases fertility in flies.

“AMP stress significantly reduced fertility across generations, with eclosion counts decreasing notably in F3 and F4 generations compared to controls.”

Model organisms

Evaluating the potential toxicity of ampicillin using Drosophila melanogaster as a model organism

Toxicology reports·Mar 11, 2025

Ampicillin shortens lifespan in flies.

“AMP exposure shortened the mean lifespan of flies”

Model organisms

Evaluating the potential toxicity of ampicillin using Drosophila melanogaster as a model organism

Toxicology reports·Mar 11, 2025