C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.
1 lab in 1 country
Human trial2
Studies in people
1 study gave amlodipine + indapamide to people and measured what changed.
Studies of Amlodipine + indapamide measured 3 outcomes; the most studied are patient-perceived health status (1 study), diastolic blood pressure (1) and systolic blood pressure (1).
Patient-perceived health status
↑upin humans1
1 study
Amlodipine + indapamide improves patient-perceived health status in humans (55.9 ± 17.0 at baseline to 78.9 ± 14.1 at 12 weeks).
“VAS scores (mean ± SD) increased from 55.9 ± 17.0 at baseline, 68.2 ± 14.5 at two weeks, 72.7 ± 14.6 at four weeks, and 78.9 ± 14.1 at 12 weeks (p < 0.001).”
“At 12 weeks, the mean SBP further declined to 127.4 ± 17.9 mmHg, corresponding to a total reduction of -29.3 mmHg (95% CI: -30.7 to -27.9; p < 0.001), while DBP dropped to 75.6 ± 10.2 mmHg, with a mean change of -12.9 mmHg (95% CI: -14.1 to -11.7; p < 0.001).”
“At 12 weeks, the mean SBP further declined to 127.4 ± 17.9 mmHg, corresponding to a total reduction of -29.3 mmHg (95% CI: -30.7 to -27.9; p < 0.001), while DBP dropped to 75.6 ± 10.2 mmHg, with a mean change of -12.9 mmHg (95% CI: -14.1 to -11.7; p < 0.001).”
In two randomized trials involving 3,299 adults with hypertension, a three-drug pill achieved virtually all its blood pressure reduction within two weeks.In two randomized trials involving 3,299 adults with hypertension, a three-drug pill achieved virtually all its blood pressure reduction within two weeks.
The pill lowered the upper blood pressure reading by 15 mmHg and the lower by 7 mmHg versus placebo at six weeks.The pill lowered the upper blood pressure reading by 15 mmHg and the lower by 7 mmHg versus placebo at six weeks.
The spread of upper blood pressure readings, measured by standard deviation, was 2.05 mmHg lower with the pill than with placebo.The spread of upper blood pressure readings, measured by standard deviation, was 2.05 mmHg lower with the pill than with placebo.