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Indapamide

Intervention

1 paper2 findings

PubChemChEBI

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

Company ties: findings with an author at a company, or from a paper whose competing-interests statement declares ties to one.

  • 1 lab in 1 country
  • 2 of 2 findings with company ties
  • Animals1

Outcomes

2

Cerebrovascular lesions

downin rats1

1 study

  1. Indapamide prevents cerebrovascular lesions in rats (0% vs 56% in surviving controls).

    “no death and no cerebral lesions were observed in animals drinking saline, to which delapril, indapamide and their combination had been added, up to the end of treatment.”

    Animalsin salt-loaded stroke-prone spontaneously hypertensive ratsdrinking saline solution31 weeks of treatment and up to 8 weeks thereafter

    Protective effects of delapril, indapamide and their combination on stroke occurrence and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats

    Arzneimittel-Forschung1 Nov 1998

Mortality

downin rats1

1 study

  1. Indapamide decreases mortality in rats (0 deaths vs ~50% in controls).

    “no death and no cerebral lesions were observed in animals drinking saline, to which delapril, indapamide and their combination had been added, up to the end of treatment.”

    Animalsin salt-loaded stroke-prone spontaneously hypertensive ratsdrinking saline solution31 weeks of treatment and up to 8 weeks thereafter

    Protective effects of delapril, indapamide and their combination on stroke occurrence and lifespan in salt-loaded stroke-prone spontaneously hypertensive rats

    Arzneimittel-Forschung1 Nov 1998

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