αhmgb1cys106
1 paper studies it5 findings
Across all fields, 1 paper: none in people yet, 1 in animals
- 1 lab in 1 country
- Funders: American Heart Association and 1 more
- Animals1
Outcomes
5TP53
downin rats1
1 study
TP53
downin rats1
αhmgb1cys106 decreases TP53 in rats.
“This effect was associated with a decreased HMGB1-DNA binding and reduced p53 expression both in vitro and in vivo.”
Animalsin vitro and in vivo
American journal of respiratory cell and molecular biology
DNA damage response
downin rats1
1 study
DNA damage response
downin rats1
αhmgb1cys106 decreases DNA damage response in rats.
“In females, the peptide therapy reduced pulmonary apoptosis, senescence, and genotoxic stress”
AnimalsSugen/Hypoxia modellungfemales
American journal of respiratory cell and molecular biology
Apoptosis
downin rats1
1 study
Apoptosis
downin rats1
αhmgb1cys106 decreases apoptosis in rats.
“In females, the peptide therapy reduced pulmonary apoptosis, senescence, and genotoxic stress”
AnimalsSugen/Hypoxia modellungfemales
American journal of respiratory cell and molecular biology
Cellular senescence
downin rats1
1 study
Cellular senescence
downin rats1
αhmgb1cys106 decreases cellular senescence in rats.
“In females, the peptide therapy reduced pulmonary apoptosis, senescence, and genotoxic stress”
AnimalsSugen/Hypoxia modellungfemales
American journal of respiratory cell and molecular biology
Pulmonary arterial hypertension
downin rats1
1 study
Pulmonary arterial hypertension
downin rats1
αhmgb1cys106 decreases pulmonary arterial hypertension in rats.
“preventive and therapeutic administration of αHMGB1Cys106 mitigated Sugen/Hypoxia-induced PAH development and progression in a sex-specific manner.”
AnimalsSugen/Hypoxia-induced severe PAH
American journal of respiratory cell and molecular biology