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Alpha-santalol + beta-santalol

Intervention

1 paper5 findings

C, W, M, H: cells, worms or flies, mice, humans. Dark: independent labs found the same change there. Light: one lab or one study. Outline: nothing yet.

  • 1 lab in 1 country
  • Model organisms1

Outcomes

5

Ubiquitin–proteasome system

upin worms1

1 study

  1. Alpha-santalol + beta-santalol activates ubiquitin–proteasome system in worms.

    “activating the SKN-1/Nrf2, autophagy, and proteasome”

    Model organismsin C. elegans strains carrying TTRWT::EGFP and TTRV30M::EGFP transgene

    Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

    Frontiers in pharmacologyJun 16, 2022

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Autophagy

upin worms1

1 study

  1. Alpha-santalol + beta-santalol activates autophagy in worms.

    “activating the SKN-1/Nrf2, autophagy, and proteasome”

    Model organismsin C. elegans strains carrying TTRWT::EGFP and TTRV30M::EGFP transgene

    Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

    Frontiers in pharmacologyJun 16, 2022

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Healthspan

upin worms1

1 study

  1. Alpha-santalol + beta-santalol improves healthspan in worms.

    “α- and β-Santalol extend the lifespan and healthspan of C. elegans strains carrying TTRWT::EGFP and TTRV30M::EGFP transgene”

    Model organismsin C. elegans strains carrying TTRWT::EGFP and TTRV30M::EGFP transgene

    Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

    Frontiers in pharmacologyJun 16, 2022

Lifespan

upin worms1

1 study

  1. Alpha-santalol + beta-santalol extends lifespan in worms.

    “α- and β-Santalol extend the lifespan and healthspan of C. elegans strains carrying TTRWT::EGFP and TTRV30M::EGFP transgene”

    Model organismsin C. elegans strains carrying TTRWT::EGFP and TTRV30M::EGFP transgene

    Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

    Frontiers in pharmacologyJun 16, 2022

TTR aggregates

downin worms1

1 study

  1. Alpha-santalol + beta-santalol decreases TTR aggregates in worms.

    “α- and β-santalol synergize to reduce wild-type (WT) and Val30Met (V30M) mutant TTR aggregates in novel C. elegans strains expressing TTR fragments fused with a green fluorescent protein”

    Model organismsin C. elegans expressing TTRWT::EGFP and TTRV30M::EGFP

    Santalol Isomers Inhibit Transthyretin Amyloidogenesis and Associated Pathologies in Caenorhabditis elegans

    Frontiers in pharmacologyJun 16, 2022

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