Aflatoxin B1

1. Aflatoxin B1 increases cellular senescence in chickens.

   “AFB1 also promoted cellular senescence in chicken hepatocytes.”

   Animalsin chicken hepatocytesliver

   PERK drives aflatoxin B1-induced chicken cellular senescence by promoting NLRP3-mediated PANoptosis

   Journal of advanced research·May 20, 2026

More on Cellular senescence

1. Aflatoxin B1 increases hepatic histopathological damage in chickens.

   “AFB1 induced hepatic histopathological damage and enhanced appearance of swollen endoplasmic reticulum (ER).”

   Animalsin chickensliver

   PERK drives aflatoxin B1-induced chicken cellular senescence by promoting NLRP3-mediated PANoptosis

   Journal of advanced research·May 20, 2026

1. Aflatoxin B1 inhibits skn-1 in worms.

   “AFB1 suppressed intestinal SKN-1::GFP translocation.”

   Model organismsintestine

   Early life long-term exposure to aflatoxin B1 induces aging and alters innate immunity associated with SKN-1/Nrf2 in Caenorhabditis elegans

   Chemico-biological interactions·Dec 13, 2024

More on skn-1

1. Aflatoxin B1 increases lipofuscin in worms.

   “At adulthood day 4 in the presence of live Escherichia coli OP50, AFB1 (2.5 μM) significantly increased lipofuscin levels (a hallmark of aging) compared to adult day 0”

   Model organismsin the presence of live Escherichia coli OP502.5 μM

   Early life long-term exposure to aflatoxin B1 induces aging and alters innate immunity associated with SKN-1/Nrf2 in Caenorhabditis elegans

   Chemico-biological interactions·Dec 13, 2024

More on Lipofuscin

1. Aflatoxin B1 decreases survival in worms.

   “in aged worms, AFB1 exposure caused a dose-dependent decrease in survival of C. elegans against P. aeruginosa PA14 infection.”

   Model organismsagainst P. aeruginosa PA14 infection

   Early life long-term exposure to aflatoxin B1 induces aging and alters innate immunity associated with SKN-1/Nrf2 in Caenorhabditis elegans

   Chemico-biological interactions·Dec 13, 2024

1. Aflatoxin B1 decreases reproduction in worms.

   “early life long-term AFB1 exposure (2.5 and 5 μM) delayed development, reduced reproduction, and shortened lifespan in C. elegans.”

   Model organisms2.5 and 5 μM

   Early life long-term exposure to aflatoxin B1 induces aging and alters innate immunity associated with SKN-1/Nrf2 in Caenorhabditis elegans

   Chemico-biological interactions·Dec 13, 2024

1. Aflatoxin B1 shortens lifespan in worms.

   “early life long-term AFB1 exposure (2.5 and 5 μM) delayed development, reduced reproduction, and shortened lifespan in C. elegans.”

   Model organisms2.5 and 5 μM

   Early life long-term exposure to aflatoxin B1 induces aging and alters innate immunity associated with SKN-1/Nrf2 in Caenorhabditis elegans

   Chemico-biological interactions·Dec 13, 2024

1. Aflatoxin B1 decreases ARID3A in human cells.

   “AFB1 downregulates ARID3A and ARID3B proteins”

   Cells

   Aflatoxin B1 downregulates ARID3 genes to overcome senescence for inducing hepatocellular carcinoma

   Toxicon : official journal of the International Society on Toxinology·Oct 2, 2024

More on ARID3A