Physical-psychological-cognitive multimorbidity
4 papers8 findings
- Humans4
Upstream
1Light-BioAge
mediatesin humans1HR 1.01
1 study
Light-BioAge
mediatesin humans1HR 1.01
Light-BioAge mediates physical-psychological-cognitive multimorbidity in humans (HR 1.01, 95% CI 1.00-1.01).
“Light-BioAge accounted for a small proportion (4.9% and 5.3%) of the total effects, with indirect effects close to the null (HR = 1.01, 95% CI: 1.00-1.01).”
Humansexploratory mediation analysisn = 4,546
Frontiers in nutrition10 Sep 2026
Associations
7Childhood food deprivation
upin humans1HR 1.17
1 study
Childhood food deprivation
upin humans1HR 1.17
Childhood food deprivation raises the risk of physical-psychological-cognitive multimorbidity in humans (HR 1.17, 95% CI 1.07-1.28).
“Further adjustment for lifestyle and health-related covariates yielded HRs of 1.17 (95% CI: 1.07-1.28) and 1.43 (95% CI: 1.25-1.63).”
Humansmoderate deprivation vs no deprivation (fully adjusted)n = 4,546
Frontiers in nutrition10 Sep 2026
Adverse adulthood experiences
upin humans1HR 1.18
1 study
Adverse adulthood experiences
upin humans1HR 1.18
Adverse adulthood experiences raise the risk of physical-psychological-cognitive multimorbidity in humans (HR 1.18 (95% CI 1.03-1.34)).
“while each additional AAE increased risk by 18% (HR 1.18; 95% CI 1.03-1.34).”
Humans
The journal of nutrition, health & aging28 Mar 2026
Adverse childhood experiences
upin humans1HR 1.19
1 study
Adverse childhood experiences
upin humans1HR 1.19
Adverse childhood experiences raise the risk of physical-psychological-cognitive multimorbidity in humans (HR 1.19 (95% CI 1.06-1.33)).
“Each additional ACE increased the hazard of PPC-MM by 19% (HR 1.19; 95% CI 1.06-1.33)”
Humans
The journal of nutrition, health & aging28 Mar 2026
Allostatic load
upin humans1HR 1.66
1 study
Allostatic load
upin humans1HR 1.66
Allostatic load raises the risk of physical-psychological-cognitive multimorbidity in humans (HR = 1.66, 95% CI: 1.16-2.38).
“High AL increased overall PPC-MM risk (HR = 1.66, 95% CI: 1.16-2.38)”
Humans
General hospital psychiatry9 Feb 2026
Body mass index
upin humans1OR 1.084
1 study
Body mass index
upin humans1OR 1.084
Body mass index raises the risk of physical-psychological-cognitive multimorbidity in humans (OR 1.084 (95% CI: 1.038, 1.133)).
“In terms of body mass index (BMI), the Q3 group exhibited odds of multimorbidity that were 1.084 (95% CI: 1.038, 1.133) times higher than those in Q1 (Ptrend < 0.001).”
Humans
BMC public health24 Jan 2026
Dietary diversity
downin humans1OR 0.803
1 study
Dietary diversity
downin humans1OR 0.803
Dietary diversity lowers the risk of physical-psychological-cognitive multimorbidity in humans (OR 0.803 (95% CI: 0.721, 0.893)).
“Similarly, the Q3 group of dietary diversity score (DDS) demonstrated an OR of 0.803 (95% CI: 0.721, 0.893), indicating a significant trend (Ptrend < 0.001).”
Humans
BMC public health24 Jan 2026
Leisure activities
downin humans1OR 0.601
1 study
Leisure activities
downin humans1OR 0.601
Leisure activities lower the risk of physical-psychological-cognitive multimorbidity in humans (OR 0.601 (95% CI: 0.529, 0.682)).
“when compared to the lowest quartile (Q1) of leisure activity (LA), the odds ratio (OR) for the highest quartile (Q3) was 0.601 (95% confidence interval [CI]: 0.529, 0.682).”
Humans
BMC public health24 Jan 2026