Advanced oxidation protein products

1. Advanced oxidation protein products increase myeloid-derived suppressor cells in mice (up to 55.2%).

   “In vivo treatment with AOPPs significantly increased the proportion of MDSCs in the bone marrow, which is up to 55.2%.”

   Animalsbone marrow4 weeks

   Effect of Advanced Oxidation Protein Products (AOPPs) and aging on the osteoclast differentiation of Myeloid-Derived Suppressor Cells (MDSCs) and its preliminary mechanism

   Biochemical and biophysical research communications·Nov 1, 2022

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1. Advanced oxidation protein products induce cellular senescence in rat cells.

   “Exposure of AOPPs to AF primary cells up-regulated NOX4 expression, induced phosphorylation of mitogen-activated protein kinases (MAPK), triggered senescence and increased IL-1β and TNF-α.”

   Cellsin vitro stimulationannulus fibrosus

   Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration

   PeerJ·Aug 2, 2022

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1. Advanced oxidation protein products increase intervertebral disc degeneration in rats.

   “Intra-discal loading of AOPPs up-regulated the expression of NOX4, p53, p21, p16, IL-1β, and TNF-α, ultimately accelerating IVDD.”

   Animalsintra-discal loading in ratsintervertebral disc

   Advanced oxidation protein products induce annulus fibrosus cell senescence through a NOX4-dependent, MAPK-mediated pathway and accelerate intervertebral disc degeneration

   PeerJ·Aug 2, 2022

More on Intervertebral disc degeneration